Preoperative hydronephrosis predicts adverse pathological features and postoperative survival in patients with high-grade upper tract urothelial carcinoma

ABSTRACT Purpose: Epidemiological studies reported conflicting results about preoperative hydronephrosis in upper tract urothelial carcinoma (UTUC). This study aimed to investigate the association between preoperative hydronephrosis and pathologic features and oncologic outcomes in patients with UTUC treated by radical nephroureterectomy (RNU). Materials and Methods: This was a retrospective, single-center cohort study of 377 patients treated by RNU without perioperative chemotherapy between January 2001 and December 2014. Logistic regression, Cox regression, and survival analyses were performed. Results: Among the 226 patients with high-grade UTUC, 132 (58%) had preoperative hydronephrosis. Multivariable logistic regression revealed that hydronephrosis was independently associated with advanced pT stage (P=0.017) and lymph node or lymphovascular invasion (P=0.002). Median follow-up was 36 months (interquartile range: 20-48 months). The 3- and 5-year overall survival (OS) rates in patients with hydronephrosis were significantly lower than in those without hydronephrosis (both P <0.001). The 3- and 5-year cancer-specific survival (CSS) rates in patients with hydronephrosis were significantly lower than in those without hydronephrosis (both P=0.001). Hydronephrosis was independently associated with OS and CSS (P=0.001 and P=0.004, respectively). Among the 151 patients with low-grade UTUC, hydronephrosis was not associated with pathologic features and postoperative survival. Conclusions: Preoperative hydronephrosis was significantly associated with adverse pathologic features and postoperative survival in patients with high-grade UTUC.

Coexistencia de un hamartoma vascular vesical y carcinoma papilar urotelial: reporte de un caso / Coexistence of a urinary bladder vascular hamartoma and urotelial papilar carcinoma: case report

El hamartoma de la vejiga urinaria es una entidad infrecuente, no hemos encontrado casos reportados en la literatura asociado a carcinoma papilar del urotelio; ambos se pueden presentar como una masa solevantada de la mucosa y es necesario el examen histopatológico para diferenciarlos. Presentamos el caso de un hombre de 73 años de edad en el que coexisten ambas entidades.

The hamartoma of urinary bladder is a infrecuent entity, we have not found case in the literature associated to urotelial papilar carcinoma, both can appear a tumor mass and the histopathology examination is necessary to differentiate them. The differential diagnosis between both tumors needs to the histopathology testing. We present a case of 73 years male in which both entities coexist.

Incidence of malignancy in microscopic haematuria: a study of 100 cases.

During June, 1998 to April, 2000, one hundred cases of microscopic haematuria were evaluated. All were symptomatic patient with age ranging from 24-68 years. 70 (70%) cases were male and 30 (30%) cases were female. Commonest presentation was dysurea 70 (70%). Urinary stone disease was the commonest cause found to be present in 25 (25%) cases. Malignant lesion was found in 16 (16%) cases of which bladder tumour was found in 10 (10%) cases.